| 1879 | Graduation of Dr. Jōkichi Takamine (the first generation students) from Department of Chemistry, Kobu-Dai-Gakko (Imperial College of Engineering) |
| 1886 | Establishment of Department of Applied Chemistry, Technical College, Teikoku Daigaku (Imperial University) |
| 1897 | Renamed as Department of Applied Chemistry, Technical College, Tokyo Imperial University |
| 1919 | Renamed as Department of Applied Chemistry, Faculty of Engineering, Tokyo Imperial University |
| 1949 | Reorganized as Department of Applied Chemistry, First Faculty of Engineering, The University of Tokyo |
| 1958 | Dr. Naoto Kameyama (professor, until 1951) was designated as Person of Cultural Merit (Applied Chemistry). |
| 1959–1961 | Reorganized into four departments: Departments of Synthetic Chemistry, Chemical Engineering, Fuel Engineering (subsequently renamed as Reaction Chemistry), and Industrial Chemistry. |
| 1961 | Dr. Yoshio Tanaka (professor, until 1942) was designated as Person of Cultural Merit (Applied Chemistry). |
| 1963 | Dr. Ryuzaburo Hara (graduated in 1913) was designated as Person of Cultural Merit (Applied Chemistry). |
| 1972 | Discovery of the Honda–Fujishima effect by Drs. Kenichi Honda (professor, until 1986) and Akira Fujishima (professor, until 2003, currently Special University Professor Emeritus). |
| 1977 | Dr. Takashi Mukaibo (professor, until 1977) was appointed to President of The University of Tokyo and designated as Person of Cultural Merit (Applied Chemistry). |
| 1986 | Confirmation of high-temperature conductivity of copper-oxide compounds by Drs. Koichi Kitazawa (professor, until 2002) and Hidenori Takagi (professor, until 2011, currently professor of school of science), et al. |
| 1994 | Three departments were reorganized into three new departments: Departments of Applied Chemistry, Chemical System Engineering, and Chemistry and Biotechnology. Reconstruction of Graduate School of Engineering, following Japanese government’s policies. |
| 1997 | Dr. Kenichi Honda (professor, until 1986) was designated as Person of Cultural Merit (Electrochemistry). |
| 2004 | Drs. Kenichi Honda (professor, until 1986) and Akira Fujishima (professor, until 2003, currently Special University Professor Emeritus) were awarded the 2004 Japan Prize. |
| 2010 | Dr. Ei-ichi Negishi (graduated in 1958) was awarded the Nobel Prize in Chemistry 2010 and was designated as the Order of Culture for 2010. |
| 2017 | Dr. Akira Fujishima (professor until 2003, currently Special University Professor Emeritus) was designated as the Order of Culture for 2017. |
| 2018 | Dr. Makoto Fujita (professor, currently University Distinguished Professor) was awarded the Wolf Prize in Chemistry 2018 |